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The space shuttle Atlantis lifts off from NASA's Kennedy Space Center in Florida—marking BioServe's first launch into orbit. (Credit: NASA)

Louis Stodieck remembers the first time he saw a space shuttle blast off from NASA’s Kennedy Space Center in Florida. In April 1991, Stodieck, an aerospace engineer, was the associate director of BioServe Space Technologies, a research center at the University of Colorado Boulder.

He had helped to design a set of test tubes that would, among other things, not spill the moment they reached space. Stodieck handed the test tubes off to a NASA crew, then watched as his work lifted away from a launchpad aboard the space shuttle Atlantis.

“I never get tired of launches,” said Stodieck, who served as BioServe’s director from 1999 to 2019 and is now its chief scientist. “The sound reaches you seconds after the launch because you’re a few miles away. When it hits you, it’s this low vibration, and you just feel it.”

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BioServe founder Marvin Luttges in 1989. (Credit: BioServe)

The BioServe team poses for a photo in 1996. (Credit: BioServe)

A test tube designed for space by BioServe. (Credit: BioServe)

BioServe, which was founded in 1987, works with scientists at companies and research institutions around the world to conduct life science experiments in space.

Today, Stodieck and his colleagues are celebrating a new milestone: BioServe’s 100th launch into orbit.

On Monday, April 21, a SpaceX Dragon capsule lifted off from a similar pad in Florida en route to the International Space Station (ISS). It carried equipment belonging to three research projects, or “payloads,” developed by BioServe. They include several colonies containing billions of bacteria and algae.

“This launch is an amazing milestone,” said Stefanie Countryman, the current director of BioServe. “It exemplifies the hard work of everybody at BioServe, not just our engineers and researchers, but also our students.”

The center has come a long way since that first launch, NASA’s , in 1991.

Researchers at the center have since sent a wide range of living things into orbit. They include single-celled organisms but also ants, silkworms, mice and an . (An 18-year-old student from Egypt proposed studying whether Nefertiti, a jumping spider, could adjust her hunting techniques in space, which she did). But BioServe has also kept one foot planted on the ground. The center’s research has generated new insights into human medical conditions like bone loss and cancer—and could even lead to facilities in the not-so-distant future that orbit Earth while making human stem cells.

“Space gives us an opportunity to look at organisms in new ways, including how they may express genes differently than they do on Earth,” Countryman said.

Single-celled astronauts

David Klaus, professor at the Ann and H.J. Smead Department of Aerospace Engineering Sciences, was a graduate student at ���ſ�app when BioServe’s first launch took off. From 1985 to 1990, he worked as a shuttle launch controller at the Kennedy Space Center in Florida and in Mission Control in Houston. Klaus is set to retire this spring and sees the 100th BioServe launch as a “bookend” on his career.

In those early days, BioServe’s work largely revolved around one challenge of conducting science from hundreds of miles above Earth—open liquids and space don’t mix.

“It’s not like taking two test tubes in a lab on Earth and mixing them together,” Klaus said. “With our early payloads, we were really just trying to figure out how we could manipulate biological fluids in a space environment and get some initial experimental results.”

BioServe began as a 5-year grant from NASA under founder Marvin Luttges, a professor of aerospace engineering sciences at ���ſ�app. Klaus explained that the center’s space test tubes include up to four sealed chambers. If you push down on a plunger, you can mix the fluids in those chambers one by one, all without exposing them to the air. BioServe has since sent thousands of its test tubes into space, and the basic design remains largely the same.

The team’s early research also revealed something surprising: BioServe scientists discovered that bacteria tend to grow better in space than they do on Earth—perhaps because they’re not being squished down by gravity. A showed that such bacteria could even be transformed into living factories for making anti-cancer drugs.

Astronaut Christina Koch uses a microscope supplied by BioServe aboard the International Space Station. (Credit: NASA)

A lab 250 miles up

In the decades that followed, BioServe’s scientific equipment wound up on NASA’s four space shuttles, the Russian space station Mir and, eventually, the ISS, which entered into orbit in 1998.

Today, astronauts on the ISS can peer through a microscope flight certified and launched by BioServe and grow cell cultures in four incubators called Space Automated Bioproduct Lab (SABL) 1, 2, 3 and 4. BioServe even supplied the refrigerator where humans on the ISS store their food. On the ground, the center runs a mission operation and control center on the ���ſ�app campus. There, BioServe staff talk to astronauts in real time on a giant screen.

“We’re replicating the sorts of biological labs that you can find at ���ſ�app in space,” said Tobias Niederwieser, a research associate at BioServe.

Astronaut Alexander Gerst loads biological cultures into a SABL incubator on the International Space Station. (Credit: NASA)

Adeline Loesch assembles space "petri dishes" containing biological organisms in a lab on the ���ſ�app campus. (Credit: Adeline Loesch)

The center has also collaborated with dozens of space agencies, universities and private companies over its history. On the current launch, for example, a company called Sophie’s Bionutrients based in the Netherlands contracted with the center to examine how —which the company hopes will lead to new kinds of algae-based meat substitutes.

The center’s most lasting contribution to science, however, may be its students. Over the years, hundreds of undergraduate and graduate students at ���ſ�app have worked for BioServe. Many have gone on to jobs at NASA and private space companies.

They include Adeline Loesch, a senior studying atmospheric and oceanic sciences at ���ſ�app. She started working at BioServe between her freshman and sophomore years. These days, she does a little bit of everything for the center: She helps to build the hardware for experiments, assembles them for flight and sits in the operations center as astronauts carry out the research.

In the fall, Loesch will start work in spacecraft and satellite flight operations for Lockheed Martin in Colorado.

“My favorite is watching the projects come full circle during the operations,” Loesch said. “Watching the research being done in real time by astronauts in space is the coolest thing ever.”

Making humans healthier from space

In the end, BioServe’s research in space doesn’t stay in space.

Roughly 24 years ago, for example, Stodieck and his colleagues for mice to live on the ISS. His team’s research has revealed new clues to why mammals lose bone mass when they leave Earth. Those insights, in turn, helped to inspire new kinds of medications for osteoporosis in people.

Niederwieser, meanwhile, is tackling what may be an even more ambitious goal—he and his colleagues are growing human hematopoietic stem cells in space. Doctors often transplant these cells into people to treat cancers like leukemia and lymphoma.

But they’re also tricky and expensive to make on Earth. In a few , Niederwieser and his colleagues discovered that stem cells, like bacteria, may grow more freely in space. Later this year, his team plans to transport a facility for producing stem cells en masse to the ISS.

That could lead to a new vision for space—one in which stations in orbit around Earth produce various treatments for human illnesses, then send them back to patients on the ground.

“Humans have been on this planet for hundreds of thousands of years and have evolved with only one gravity,” Stodieck said. “It’s really been a privilege to understand how organisms work in another environment.”

Stodieck didn’t travel to Florida for Monday’s launch, but Klaus was there to see SpaceX’s Falcon 9 rocket roar off the launchpad. Before he left, he was feeling wistful about seeing his old stomping grounds again.

“I'm looking forward to going down there and reminiscing a little bit,” Klaus said. “I’ll drive around and look at the base—a little 40-year flashback to where my career started.”��